Ukubuka Izinketho Zakho
Izinkinga ze-neurotransmitter eziningana (izithunywa zamakhemikhali ebuchosheni) zihlukunyezwa nge- fibromyalgia (i-FMS) nesifo esingapheliyo sokukhathala ( ME / CFS ). Ngenkathi uzwa kabanzi mayelana ne-serotonin ne-norepinephrin, abanye abaningana bangahle baphinde balinganise.
I-GABA neurotransmitters ne-glutamate zombili zibonakala zihlukunyezwa ku-FMS naku-ME / CFS. Izinga le-glutamate noma umsebenzi kubonakala sengathi uphezulu, kanti amazinga we-GABA noma umsebenzi ubonakala sengathi uphansi.
I-glutamate ivuselela-futhi ingaba ngaphezu kweqile-ubuchopho bakho, kuyilapho i-GABA igxilisa phansi. Ukungalingani kwabo kungase kube nomthwalo wemfanelo, okungenani ngeyingxenye, ngokukhathazeka okuhambisana nalezi zimo kanye nezinye izimpawu. (Ngaphezulu kwalokho, bheka iGABA & Glutamate: Ingxenye 1. )
Ukuguqula umsebenzi walezi zindlela ze-neurotransmitter kungasiza ekunciphiseni izimpawu.
Ukudla & Izithako ze-GABA / Glutamate Umsebenzi
Izithako zokuguqula umsebenzi we-GABA kanye ne-glutamate ebuchosheni bakho azihloliswanga ngokuqondile nge-FMS ne-ME / CFS, kodwa sinolwazi olujwayelekile ngabo.
Ifomu lobuchwepheshe le-GABA litholakala njengesengezo. Kodwa-ke, umbono wezokwelapha wamanje uwukuthi awuwudluli umkhawulo wegazi-ubongo (BBB) ngakho-ke awwenzi lutho ukulungisa ukungalingani kwe-neurotransmitter.
Ngokudabukisayo, ungakwazi ukwandisa ukukhiqizwa kwe-GABA ngokwandisa i-glutamate, ngoba umzimba wakho usebenzisa i-glutamate ukukhiqiza i-GABA.
Ukuze ukhiqize ukukhiqizwa kwe-glutamate, kungasiza ukwengeza izandulela ze-glutamate (izinto umzimba wakho ezisebenzisayo ukuzenza) ekudleni kwakho noma ekwengeziwe.
Abanye abahamba phambili bahlanganisa:
- 5-HTP : Umzimba wakho uguqula i-5-HTP ibe yi-serotonin, futhi i-serotonin ingakwazi ukuthuthukisa umsebenzi we-GABA. I-5-HTP yindlela yokwenza i-tryptophan, etholakala ku-turkey. Kodwa-ke, imithombo esekelwe ukudla ye-tryptophan ayicatshangwa ukuthi iwele i-BBB ngendlela e-5-HTP eyenziwa ngayo.
- I-Glutamine: Umzimba wakho uguqula le-amino acid ibe yi-glutamate. I-glutamine iyatholakala efomini lokufakazela futhi ikhona enyameni, enhlanzi, emaqanda, ubisi, ukolweni kanye nemifino.
- I-taurine: Le-amino acid ikhonjiswe kumagundane ukuguqula amazinga obuchopho bobabili i-GABA ne-glutamate. Ungayithatha ifomu lokufakazela futhi uluthole ngokwemvelo ekudleni nasezinhlanzi zasolwandle. I-Taurine ivame ukungezwa kweziphuzo zamandla.
- I-Theanine : Leli gciwane le-glutamate livela kumsebenzi ophansi we-glutamate ebuchosheni ngokuvimbela ama-receptors ngenkathi futhi kukhulisa amazinga we-GABA. Itholakale ngokwemvelo itiye futhi iyatholakala njengengezela.
I-probiotic okuthiwa i- Lactobacillus rhamnosus ingabuye ishintshe umsebenzi we-GABA ebuchosheni bakho, ngokusho kocwaningo luka-2011. Abacwaningi bathi amagundane adla ama-bacteria ayenamazinga aphansi okukhathazeka uma efakwe ezimweni ezicindezelayo. Noma kunjalo, lokhu kudinga ukucwaninga okuningi ngaphambi kokuthi kube yisincoma.
Ngaphambi kokuba uqale izithako ezintsha noma wenze izinguquko ezibalulekile zokudla, khuluma nodokotela wakho kanye nemithi mayelana nezingozi ezingase zibe khona kanye nokusebenzisana kwezidakamizwa . Ukuze uthole ulwazi mayelana nokuqala ama-supplements, bheka: Izinto ezingu-7 Okudingeka Uzazi Ngezidingo .
Izidakamizwa ezenza i-GABA ne-Glutamate Umsebenzi ku-Brain
Izidakamizwa eziningana okwamanje emakethe zishintsha umsebenzi wezobuchopho we-GABA no-glutamate.
Abaningi bahlolwe futhi / noma basetshenziselwa ukwelashwa kwe-FMS, kodwa kuncane kakhulu nge-ME / CFS.
Lezi zidakamizwa zibizwa ngokuthi i-agonists. Ayibanga amazinga we- neurotransmitter ukuba avuke kodwa kunalokho ukwandisa umsebenzi ngokuvuselela ama-receptors. Ngokuyinhloko, benza ubuchopho bakho basebenzise okuningi kwalokho okukhona kakade.
I-GABA agonists ihlanganisa:
- I-Benzodiazepines: Lezi zidakamizwa zicindezela isimiso sezinzwa zomphakathi. I-benzodiazepines evamile ihlanganisa i-Ativan (lorazepam), iKlonopin (clonazepam), i-Valium (diazepam) no-Xanax (alprazolam). Ngezinye izikhathi i-Benzodiazepines ibhalwa i-FMS, ikakhulukazi lapho ukulala nokukhathazeka kukhona.
- I-Xyrem (i-oxybate ye-sodium) & i-GHB (i-Gamma-Hydroxybutyric acid): Lezi zidakamizwa ezihlobene eduze nazo zicindezela isimiso sezinzwa zomphakathi. Igama lomgwaqo i-GHB yiyona " idakamizwa yokudlwengula idethi ." I-Xyrem ivunyelwe ezinye izibonakaliso ze-narcolepsy, futhi izifundo zibonise ukuthi ziyasebenza njengokwelashwa kwe-FMS; Kodwa-ke, i-US Food and Drug Administration (i-FDA) yase-United States yalahla i-FMS ngokukhathazeka kokuphepha.
- I-Non-Benzodiazepine Hypnotics: Leli klasi lezidakamizwa lihlanganisa imithi eleleka yokulala i-Ambien (zolpidem), i-Sonata (zeleplon) ne-Lunesta (eszopiclone). Lezi zidakamizwa zihluke ngokwemvelo kusuka ku-benzodiazepines kodwa zisebenza ngokufanayo. Ezinye izifundo (kufaka phakathi i-Gronblad neMoldofsky, ngezansi) ziye zabonisa ukuthi leli klasi lezidakamizwa lingathuthukisa ukulala futhi mhlawumbe ubuhlungu ku-FMS. Ayikho yalezi zidakamizwa ezedlule ngaphambi kokuba i-FDA ivunywe.
I-Yoga ingawandisa i-GABA?
I-Yoga ngokuvamile ikholelwa ukuthi iyancipha. Kungenzeka yini ukuthi ikhulise i-GABA ebuchosheni? Esinye isifundo esincane sibonisa ukuthi kungenzeka. Abacwaningi babike ukuphakama kwama-27% emazingeni e-post yoga eGABA kwabasebenzi abayisishiyagalombili.
Lokhu kuyisifundo esisodwa kuphela, ngakho-ke sidinga ucwaningo olwengeziwe ukuthi ngabe i-yoga iphakamisa ingqondo ye-GABA nokuthi ngabe yenza okungaphezu kwemisebenzi efanayo.
I-Neurotransmitter Dysregulation
Uma ukholwa ukuthi uneGABA / glutamate dysregulation, kufanele ukhulume nodokotela wakho ngezinketho zokwelapha. Khumbula ukuthi ngisho nemithi yokwelapha ingaba nemiphumela emibi kakhulu.
Funda kabanzi:
Imithombo:
I-Bravo JA, et. al. Izinqubo ze-academy of science ye-United States of America. 2011 Sep 20; 108 (38): 16050-5. Ukungena kwe-Lactobacillus uhlobo lulawula ukuziphatha ngokomzwelo nokukhulumisana okuphakathi kwe-GABA emgundini nge-vagus nererve.
Jacobs GE, et. al. Intuthuko ye-neuro-psychpharmacology ne-psychiatry yezinto eziphilayo. 2010 Apr 16; 34 (3): 486-91. Amazinga we-hypothalamic glutamate emva kokugqugquzela kwe-serotonergic.
I-Malemud CJ. I-rheumatology yemitholampilo nokuhlolwa. 2009 Sep-Oct; 27 (Isl. 56): S86-91. Gxila ezimweni zobuhlungu kanye ne-pharmacotherapy ekwelapheni kwe-fibromyalgia syndrome.
Molchanova SM, Oja SS, Saransaari P. Izinqubo zomphakathi wesentshonalanga wezokwelapha. 2007; 50: 95-7. Umphumela we-taurine ekugxilweni kwe-glutamate, i-GABA, i-glutamine ne-alanine emgqeni we-ratat kanye ne-hippocampus.
I-Spitzer AR, Isikhwama se-Broadman M. Pain Practice. 2010 Jan-Feb; 10 (1): 54-9. Ukwelashwa kwe-narcoleptiform yokulala ukugula ekuguleni okungapheli kwesifo kanye ne-fibromyalgia ne-sodium oxbate.