Ingabe Izifo Zama-Alzheimer Zinezigciwane Ezifana Nezifo Ezivamile?
Ngabe usangazibuza ukuthi ungakwazi yini ukuthola " isifo se-Alzheimer " ukuchitha isikhathi nabantu abanakho? Qinisekisa ukuthi, ukubamba isandla sikagogo noma ukumnika isikhonkwane ngeke kukunike isifo se-Alzheimer's. Futhi angeke athathe umsebenzi njengomsizi ongumhlengikazi oqinisekisiwe ekhaya lasebekhulile futhi esebenzisa isikhathi sokugqoka njalo , ukugeza nokunakekela abantu endaweni yokuphepha kwengqondo ephephile .
Ucwaningo mayelana nokuthi Izifo Zama-Alzheimer Zisakazeka kanjani
Ngenkathi isifo se-Alzheimer singasakazwa ngokuxhumana nabanye, olunye ucwaningo ngamagundane lubonakala lubonisa ukuthi lungaba nengxenye ethile yenkampani esithathelwanayo, mhlawumbe ehlobene nemikhonto (amaprotheni amaseli obuchopho kudingeka asebenze). Ezifo ze- prion , kuhlanganise nesifo seCreutzfeldt-Jakob, amaprotheni e-prion aqala ukugoqa ngendlela engavamile bese ethelela ezinye izilonda ezinempilo ezihlangana nazo emzimbeni, okwenza amaseli afe emcimbini nasekudemeni kwengqondo ukuthuthukisa. Nakuba izimali ezingenampilo zisabalalisa ngaphakathi komuntu, cishe akuyona ingozi yesifo esithinta abanye abantu abakulowo muntu, kuhlanganise namalungu omndeni noma labo abanakekela lowo muntu.
Izifundo ngezinja
Ososayensi benza ucwaningo ngamagundane, bathatha amagundane aphilile futhi bawafaka ngeprotheni ye-beta amyloid kusuka ebuchosheni bezinja eziye zakhiwa ukuthuthukisa isifo se-Alzheimer futhi zibonise ukulahleka kwememori .
Abacwaningi bathola ukuthi amagundane ayethole umjovo ekugcineni athuthukisa amaprotheni afanayo ekwakheni ubuchopho bawo kanye nokulahlekelwa inkumbulo ukuthi amagundane anesifo se-Alzheimer.
Abacwaningi base bezama ukulawula amaprotheni ayenesifo ngendlela yomlomo, amehlo, nephunga, kanye ne-intravenously, ezimpundeni ezinempilo futhi bathole ukuthi lezi zinambuzane azizange zibe nezibonakaliso zesifo se-Alzheimer.
Ucwaningo lwesibili olufanayo lathola ukuthi amagundane enempilo ayenze okulinganayo ne-Alzheimer's uma ubuchopho babo bejojowe ngezicubu zobuchopho ezigulini zabantu base-Alzheimer's.
Ukutadisha okuPhezulu nabantu
Ucwaningo oluthile oluthile (isifundo esiqhathanisa abantu abavezwe esicelweni esithile kulabo ababengekho) kwakuhlanganisa ukulandela abantu abangaphezu kuka-6100 abaye bajova ngaphambilini ngama-hormone ekukhuleni kwabantu. Abacwaningi bahlola lawo mahomoni futhi bathola ukuthi (ngaleso sikhathi bengazi), babenezinani ezincane zamaphrotheni ama - tau ne-beta amyloid akhona ebuchosheni babantu abane-Alzheimer's. Lezi zizwe ziye zaqapha ukuhlola ukuthi zenze isifo se-Alzheimer. Kuze kube manje, akekho omunye wabahlanganyeli oye wahlakulela isifo se-Alzheimer's, nakuba iningi lisengumfana osemusha ngenxa yokuqala kwengqondo yokuqala komqondo.
Ingabe Izinsimbi Zensimbi Ezingenasici Ziyosakaza Izifo Zama-Alzheimer?
Kwesinye sezifundo kanye namagundane achazwe ngenhla, abacwaningi bafaka izintambo zensimbi ezingenasici nangamanani amancane amaprotheni anesifo se-Alzheimer futhi babafaka emacinini amagundane aphilile. Bathola ukuthi lezi zinja kamuva zathola isifo se-Alzheimer, kodwa kuphela uma izintambo seziphekwe ngaphambi kokuba zifakwe esikhundleni se-plasma inzalo, indlela ephumelela kakhulu yokubangela inzalo.
Abacwaningi baphenye ngalokhu kungenzeka ngoba ukuhlolwa kwangaphambilini kubonise ukuthi isifo seCreutzfeldt-Jakob , isifo esiyinkimbinkimbi okuthiwa ngezinye izikhathi ngokuthi "isifo sofuba sezinkomo," singasakazwa kwesinye isiguli kuya kwesinye ngokusebenzisa ukusetshenziswa kwezixhobo zokuhlinzwa ezingazange zenziwe ngokugcwele, kanye nangezinye izindlela.
Ingabe Kukhona Ingozi Yokutheleleka Ngezifo Zama-Alzheimer?
Isayensi isasebenza ekunqumeni ukuthi yini ngempela ebangela isifo se-Alzheimer. Siyazi ukuthi izinto ezinobungozi ezifana nobudala, izakhi zofuzo, umlando womndeni nendlela yokuphila konke kuyingxenye yesithombe. Kungenzeka futhi ukuthi impahla ephathekayo njengama-prions angabandakanyeka esifweni se-Alzheimer, kodwa lokhu kungenakuvinjelwa ngalesi sikhathi futhi kusekelwe ekucwaningeni kokuqala ngamagundane.
Uma kubonakala ukuthi ama-prions adlala indima e-Alzheimer's disease, kubalulekile ukukhumbula ukuthi izifo ze-prion azifaki ngokuxhumana okungavamile noma okuthandana nomzimba nabanye. Ngakho-ke, qhubekani nibambe lowo muntu one-Alzheimer's. Isifo sabo asithelelanga nganoma iyiphi indlela, futhi bangathola ezinye izinzuzo ezihlobene nokuthinta ngokomzimba kubantu abane-dementia , kubandakanya ukunciphisa ukucindezeleka kwegazi, ukunciphisa ubuhlungu nokunciphisa ukuziphatha okuyinselele ekudemeni kwengqondo .
Izwi kusuka
Akuyona into engavamile ukukhathazeka ngokuchazwa yisifo, ikakhulukazi uma ungayazi kahle isimo noma ukuthi kungani umuntu ekhulayo. Nakuba kunezinto eziningana esingaziqondi okwamanje mayelana nesifo se-Alzheimer, siyazi ngokuqiniseka ukuthi ukuchitha isikhathi nabantu abane-Alzheimer's, ukubakhombisa noma ukuzinakekela ngeke kubangele ukuthi uthuthukise i-Alzheimer's.
Imithombo:
I-JAMA Neurology. 2013, 70 (4): 462-8. Ukuhlolwa kokungenwa kwe-alzheimer kanye ne-Parkinson isifo samaprotheni kulabo abamukeli be-hormone ekukhuleni komuntu. http://www.ncbi.nlm.nih.gov/pubmed/23380910
Journal of Neuroscience.15 Meyi 2000, 20 (10): 3606-3611. Ubufakazi be-Seeding ye-β-Amyloid yi-Intracerebral Infusion ye-Alzheimer Brain Extracts ku-β-Amyloid Precursor Amaphenyi-Protein-Transgenic. > http://www.jneurosci.org/content/20/10/3606
I-Psychiatry ye-Molecular 17 , 1347-1353 (Disemba 2012) | i-doi: 10.1038 / mp.2011.120. Ukukhishwa kwe-De novo kokuthunyelwa kwe-amyloid-β ku-vivo. https://cen.acs.org/articles/90/i27/Alzheimer-Prion-Connection.html
Izinqubo ze-National Academy of Sciences yase-United States of America. Agasti 4, 2009.106 (31). Ukwehla kwe-cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation. http://www.pnas.org/content/106/31/12926.full