Akekho owazi ukuthi kubangelwa yini i-fibromyalgia, futhi lokho kuyiqiniso elimangalisa kubantu abayizigidi ezine abakholelwa ukuthi babhekene nesifo e-US Abanye ososayensi baye basikisela ukuthi i-fibromyalgia "iyinkinga yokuqwashisa phakathi" lapho amangqamuzana e-nervous in the brain and umthambo womgogodla usebenza kahle noma amasistimu okuvimbela ukuguqula ukucubungula kwezibonakaliso zobuhlungu ayasebenza.
Abanye, okwamanje, bakholelwa ukuthi i-fibromyalgia ayiyona isifo esisodwa (somzimba) kodwa isilawulwa kakhulu-noma kwezinye izimo ngaphezulu-ngokucindezeleka kwengqondo. Lokhu kuphakamisa ukuthi i-fibromyalgia yisifo esiyinkimbinkimbi lapho ezinye izimpawu zingase zibe umphumela wesistimu yezinzwa ezingasebenzi, kanti abanye (njengokulala noma isimo sengqondo) kungenza noma kuthinte ubuhlungu obungapheli obujwayelekile esibubona njenge-fibromyalgia.
Akekho ongasho ngokuqinisekile ngalesi sigaba. Lokho esikwaziyo ukuthi izici ezithile zingakubeka engozini yokwanda kwe-fibromyalgia, kufaka phakathi ubulili, ubudala, ukucindezeleka kwengqondo, kanye nezakhi zofuzo.
Ubulili
Ukukhuluma ngesitatimende, abesifazane banamathuba angaphezu kwesishiyagalolunye ukuze bathole i-fibromyalgia kunamadoda. Nakuba isizathu salokhu akucaci ngokuphelele, ama-hormone ocansi akholelwa ukuthi adlala indima ebalulekile ekusabalaliseni kwesifo kuphela kodwa ubukhulu nobukhulu bezimpawu .
Lokhu kukhonjiswe ngokuyingxenye yocwaningo lwango-2017 olwanyatheliswa encwadini ethi Gynecology and Endocrinology ebonisa ukuthi ukukhanya kwezimpawu ze-fibromyalgia kwenzeka ngokuyinhloko ngokuqala kwezimpawu zokuqala. Eqinisweni, abesifazane abanesifo esibucayi se- premenstrual syndrome (PMS) babenamathuba angaphezu kuka-20 amathuba okuba ne-cyclic fibromyalgia flares kunabesifazane abanezinsana ezincane ezingenazo izimpawu ze-PMS ezazingekho engozini yesifo.
Amanye amacala avela ukuthi ahambisana nokuqala kokumisa esikhathini lapho amazinga e-hormone azokwehla ngokuphawulekayo. Lokhu kuqhubeka nokusekela indima ye-estrogen ezinhlakalweni ze-cyclic fibromyalgia njengoba kunamazinga we-estrogen ewela ngesikhathi sokuya esikhathini. Futhi, hhayi estrogen kuphela kodwa testosterone, kanye.
Lokhu kusikisela ukuthi i-testosterone, i-hormone yamadoda, ingase idale indima ekuthuthukiseni izimpawu ze-fibromyalgia kubantu . Ngenkathi ucwaningo luhluleka, isifundo se-2010 esikhungweni sezokwelapha saseYunivesithi saseNebraska sibonise ukuthi ukwehla okuqhubekayo emazingeni e-testosterone njengendoda eneminyaka yobudala kuboniswa ukunyuka kokuvama kanye nobukhulu bezinhlungu zomzimba we-musculoskeletal of fibromyalgia.
Abanye abacwaningi basikisela ukuthi izinga le-fibromyalgia phakathi kwamadoda, empeleni, lingaphezulu kakhulu kunalokho okulinganiselwe, ikakhulukazi ngoba amadoda angenakudlula ukufuna ukwelashwa ubuhlungu obungapheli okwakungapheli kwabesifazane.
Ubudala
Abantu abaningi bacabanga ukuthi i-fibromyalgia iyisifo esithinta abesifazane abasemuva-menopausal (umbono owawuthonywa kakhulu yizikhangiso ze-TV ezithinta abesifazane kuphela kuma-50s no-60s abanenkinga yokugula). Eqinisweni, i-fibromyalgia ivame ukukhula ngesikhathi sokubeletha komama wesifazane futhi ngokuvamile ihlolwe ukuthi iphakathi kweminyaka engu-20 no-50.
Ngokuvamile, ingozi ivame ukwanda njengoba uthola wena osekhulile. Nakuba ingozi enkulu ye-fibromyalgia iphakathi kwamaphesenti amabili namaphesenti amane, izokhula ibe ngamaphesenti angama-8 ngesikhathi uvula ama-80.
Ngalokho kuthiwa, ngezinye izikhathi kungathatha iminyaka ngaphambi kokuba ubuhlungu obuhlala njalo bubukeka njenge-fibromyalgia. Eqinisweni, ucwaningo olwenziwa ngo-2010 olwenziwa nguMnyango Wezemfundo Rheumatology e-King's College London luphetha ngokuthi kuthatha isilinganiso seminyaka engu-6.5 kusukela ekuqaleni kwezimpawu zokuthola ukutholakala okuqinisekisiwe kwalesi sifo.
Ngokuvamile, i-fibromyalgia ingabhekisela izingane kanye nentsha ngendlela engafani nhlobo ye-disorder eyaziwa ngokuthi i- juvenile fibromyalgia syndrome (i-JFMS) .
Ukucindezeleka kwengqondo
Ukucindezeleka kungase kube yimbangela ye-fibromyalgia, nakuba kuyinto ethile yenkukhu-yeqanda. Ngenkathi siyazi, isibonelo, ukuthi i-fibromyalgia ihlale ikhona ngokukhathazeka okuhlobene nokucindezeleka njengokungapheli kwesifo sokugula (CFS) , ukucindezeleka , isifo sofuba esisathukuthela (IBS) , kanye nesifo sokucindezeleka ngemuva kokucindezeleka (PTSD), asikho uqiniseke ngokuphelele ukuthi ubuhlobo busebenza kanjani.
Ngemibandela efana ne-PTSD, inhlangano ibonakala ibonisa ukuthi izimpawu zengqondo zingaholela kwezinye izinto ngokomzimba, mhlawumbe ngokwemvelo (ngokushintsha imisebenzi ye-physiologic), psychosomatically , noma kokubili. Nge-CFS, ukucindezeleka, ne-IBS, ubuhlobo bungaba yimbangela-futhi-effect, ngokucindezeleka okuthile kwengqondo okudala izimpawu zomzimba kanye nezimpawu ezithile zomzimba ezibangela ukucabanga kwengqondo / ukuqonda.
Ucwaningo oluthile oluxubile lwe-fibromyalgia lisikisela ukuthi kunama-subtypes amane:
- I-Fibromyalgia engenazo izimo zengqondo
- I-Fibromyalgia enokucindezeleka okuhlobene nobuhlungu
- I-Fibromyalgia ihlangene nokucindezeleka komtholampilo
- I-Fibromyalgia ngenxa yokubambisana (ukuthambekela kokubhekana nokucindezeleka kwengqondo ngezimpawu zomzimba, njengokungathi kungenzeka nge-PTSD)
Ngokufanayo, izinkinga zokulala zihlotshaniswa ne-fibromyalgia. Ngenkathi ukuphazamiseka okuthile kokulala njengokuphefumula kwe- sleep apnea kungase kube khona nge-fibromyalgia futhi kube nomthelela emazingeni aphezulu okukhathala okungapheli, nezinye izindaba eziphathelene nokulala njengokuqala kokulala (i-hypnic jerks) nokulala okuphukile kukholakala ukuthi kubangelwa ukungasebenzi kwe- neurotransmitter phakathi isimiso sezinzwa.
Lokho esikwaziyo, ukuthi noma yikuphi imbangela noma umphumela, ubuthongo bokubuyisela (lapho amaphethini okulala ajwayelekile) axhumene ngqo nokunciphisa izimpawu zobuhlungu.
I-Genetics
I-Genetics igalela ngokucacile ekuthuthukiseni i-fibromyalgia, okungenani ingxenye, nakuba kungase kungabi ngenxa yokushintshashintsha kwesakhi esisodwa kodwa kuguquguquke okuphawulekayo nokungafani. Njengamanje, ososayensi abakakaze bavule inhlanganisela yamakhulu ezinhlobonhlobo zokulawula ubuhlungu emzimbeni wakho
Indima ye-genetic in fibromyalgia iboniswe ngokuyingxenye ngokubuyekezwa okunzulu kwezifundo ezivela ku-Chonnam National Medical Hospital eKorea okukhombisa izinga elilinganayo lefa phakathi kwamalungu omndeni wokuqala we-fibromyalgia. Kusukela ngo-1989 kuya ku-2013, iningi locwaningo luye lwabonisa ukuthi ukuba nomzali noma umntakwethu nge fibromyalgia kwandisa ingozi yakho isifo kusuka ngamaphesenti angama-26 kuya kuma-28, kanti ilungu lomndeni eliphakeme lesibili liyakwandisa ingozi ngamaphesenti angama-19 .
Ngenkathi ucwaningo luqhubeka, kunobunye ubufakazi bokuthi abantu abanokuthiwa yi-5-HT2A receptor 102T / C i-polymorphism ingase ibe engozini ephezulu ye-fibromyalgia.
Imithombo:
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