I-Glutathione, eyaziwa nangokuthi i-GSH, i-molecule ithola ngokwemvelo emzimbeni wakho. Ekhiqizwa yisibindi, i-glutathione yakhiwe ngamamino acid amathathu: L-cysteine, glycine, ne-L-glutamate. I-Glutathione icatshangelwa ukuthi inikeza imiphumela yokuvimbela i-antioxidant, kanye nokugqugquzela amasosha omzimba. Abagqugquzeli bathi izithako ze-glutathione zingasiza ukuphatha nokuvimbela izimo zempilo eziningana.
Futhi itholakale ekudleni okuthile (njengezithelo nemifino), i-glutathione ithengiswa ngendlela yokudla yokudla. Nakuba i-glutathione idlala indima ebalulekile emzimbeni, izithako ze-glutathione zomlomo zigawulwa kuma-antioxidants amathathu, kanti izinzuzo kucatshangwa ukuthi zivela ku-L-cysteine.
Ukusetshenziswa
I-Glutathione kuthiwa ivikela ngezinkinga eziningi zempilo, okubandakanya: ukuphuza utshwala , isifo se-Alzheimer, isifo se-asthma , isifo sokuqina kwesifo sofuba , i-autism, i- cataracts , isifo sokuphelelwa yisifo sikashukela , i- glaucoma , isifo senhliziyo , isifo sofuba , i- cholesterol ephezulu , isifo sesibindi, i- osteoarthritis , Isifo seLyme, nesifo sikaParkinson .
Ngaphezu kwalokho, i-glutathione kuthiwa iguqula inqubo yokuguga, ivimbele umdlavuza, futhi igcine inkumbulo.
Izinzuzo zezeMpilo
Ukugcina amazinga aphezulu e-glutathione kubalulekile empilweni yakho, ngokusho kombiko we-2004 oshicilelwe kuyi- Journal of Nutrition . Abalobi babika ukuthi i-glutathione idlala indima ebalulekile ekuzivikelweni kwe-antioxidant, ukuwohloka kwezakhi, nokulawulwa kwezinqubo eziningi eziphilayo (kuhlanganise nokuphendula kwamagciwane).
Abalobi bathi futhi ukuphelelwa amandla kwe-glutathione kunomthelela ekucindezelekeni kwe-oxidative , okwenza kube nokuthelela ukuthuthukiswa kwezifo eziningi (kuhlanganise nesifo so-Alzheimer, isifo sika-Parkinson, isifo sesibindi, i-cystic fibrosis, i-sickle cell anemia, umdlavuza, isifo senhliziyo, isifo sofuba nesifo sikashukela).
Ngenkathi ucwaningo olwenziwe ngokusetshenziswa kwe-glutathione lungenalutho, kunobunye ubufakazi bokuthi i-glutathione inganikeza izinzuzo ezithile uma kuthathwa ifomu lokufaka isicelo (kodwa futhi, kungenzeka ngenxa yokwanda kwe-L-cysteine njengoba i-glutathione igawulwa ngama-amino acid) .
Nakhu ukubuka okutholakala okuyinhloko kwezifundo ezikhona:
Ulcerative Colitis
Izifo ezivuthayo zezifo ezinjenge-ulcerative colitis zibhekene nokucindezeleka okwenziwe nge-oxidative, futhi i-glutathione iyi-antioxidant eyinhloko emasongweni emathunjini. Ucwaningo olusekelwe ezilwaneni lubonisa ukuthi i-glutathione supplementation ingasiza ekwelapheni i-ulcerative colitis. Esifundweni sango-2003 eshicilelwe ku- Digestive and Liver Illness , isibonelo, ososayensi bathola ukuthi ukwesekwa kwe-glutathione kwandisa kakhulu umonakalo ekoloni kumazinyane ezine-colitis.
Impilo Yenhliziyo
Ekuhlolweni kwamagundane, abalobi besifundo se-2001 kusukela ku- American Journal of Physiology bathola ukuthi ukuhlanganiswa kokuhlanganiswa kwe-glutathione nokuqeqeshwa kokuvivinya umzimba kungasiza ekukhuliseni amandla e-antioxidant futhi kuvikeleke ekulimaleni komonakalo wegazi futhi kunciphise enhliziyweni umsebenzi obangelwa ukuphindaphinda kwe-ischemia (ukubuyiselwa ukugeleza kwegazi kuya endaweni ewake yabhekana nokungahambi kahle kwegazi).
I-Autism
I-Glutathione ibonisa isithembiso ekwelapheni kwe-autism spectrum disorders, iphakamisa isifundo esincane esanyatheliswe kuyi- Medical Science Monitor ngo-2011. Ukuze kuhlolwe, izingane ezingu-26 (abaneminyaka emithathu kuya kweyishumi) ezine-disism spectrum disorder zanikezwa amaviki ayisishiyagalombili ukwelashwa nge-glutathione i-supplement noma i-glutathione esetshenzisiwe (uhlobo lokwelapha okubandakanya ukuletha izithako ezisebenzayo esikhumbeni).
Imiphumela yabonisa ukuthi izithako ze-glutathione zisize ukwandisa amazinga ka-glutathione wabahlanganyeli ngezinga elithile. Abalobi bezocwaningo bacela ucwaningo oluqhubekayo ekusetshenzisweni kwezithako ze-glutathione kanye nokukwazi ukuthuthukisa izimpawu ze-autism spectrum disorders.
Isikhumba
Imikhiqizo eminingi yokunakekelwa komuntu siqu equkethe i-glutathione idayiswa ngemiphumela ebizwa ngokuthi i-skin-whitening. Le mikhiqizo ihlanganisa amasobho nama-creams. Kodwa-ke, abanye abantu bathatha izithako ze-glutathione zesikhumba-ukugcoba. Nakuba i-glutathione ivame ukufakwa njengesisombululo semvelo sokuhlanza isikhumba, akukho ukusekelwa kwesayensi kwalesi simangalo.
Ukusetshenziswa okungaxhunyiwe kanye nezifo
Kwezinye izimo, ochwepheshe bezempilo baqondisa i-glutathione ngokusebenzisa i- IV . Lapho kunikwa i-intravenously, i-glutathione ngokuvamile isetshenziselwa ukuphatha izimo ezifana nesifo sika-Parkinson, isifo sokuqina kwesifo sofuba nesifo sikashukela. Ngaphezu kwalokho, ukulawula i-glutathione nge-IV ngezinye izikhathi kusetshenziselwa ukwelapha imiphumela emibi ye- chemotherapy , ukwelashwa kwe-hemodialysis, nokuhlinzwa kokudlula.
Ochwepheshe bezeMpilo ngezinye izikhathi bajoba glutathione ukuvikela imithi emibi ye-chemotherapy noma ukuphatha ukungasebenzi.
Okuqhamuka uma udla imishanguzo
Ngenxa yokuntuleka kocwaningo, okuncane akuyazi ngemiphumela emibi yokusebenzisa izithako ze-glutathione. Kodwa-ke, kunokukhathazeka okunye ukuthi ukusebenzisa izithasiselo ze-glutathione kungabangela ukucindezela nokuvimbela. Ukwengeza, abanye abantu bangase babhekane ne-allergenic ezithebeni ze-glutathione supplements (njenge-rash).
Lapho Uzoyithola khona
Etholakala kakhulu ukuthengwa ku-intanethi, izithako ze-glutathione nemikhiqizo yokunakekelwa komuntu siqu ye-glutathione zithengiswa ezitolo eziningi zemvelo zokudla, izidakamizwa, kanye nezitolo ezikhethekile ezisekelweni zokudla.
Ukusebenzisa Imoya YezeMpilo
Noma yiziphi izinzuzo ze-glutathione ezongezwa ngomlomo zingase zibe ngenxa yokwanda kwe-L-cysteine. Ezinye izithako, njenge- N-acetylcysteine , zinganikeza i-L-cysteine edingekayo ekukhuliseni amazinga e-glutathione emzimbeni ngendlela engabizi kakhulu.
Ngenxa yokuntuleka kocwaningo olusekelayo, kusheshe kakhulu ukutusa i-glutathione nganoma yisiphi isimo sezempilo. Uma ucabangela ukusebenzisa i-glutathione ngesimo, qiniseka ukuthi ubonane nodokotela wakho ngaphambi kokuqala isimiso sakho sosizo. Ukwelapha isimo esingapheli nokugwema noma ukubambezela ukunakekelwa okujwayelekile kungaba nemiphumela emibi kakhulu.
Imithombo
Kern JK, Geier DA, Adams JB, Garver CR, Audhya T, Geier UMs. "Isivivinyo somtholampilo se-glutathione supplementation ku-autism spectrum disorders." I-Med Sci Monit. 2011 Dec; 17 (12): CR677-82.
I-Loguercio C, D'Argenio G, iDave Delle M, i-Cosenza V, i-Della Valle N, i-Mazzacca G, i-Del Vecchio Blanco C. "I-Glutathione supplementation ithuthukisa umonakalo we-oxidative ku-colitis yokuhlola." Gweba i-Dis ye-Liver. 2003 Sep; 35 (9): 635-41.
URamires PR, Ji LL. "I-Glutathione supplementation nokuqeqeshwa kwandisa ukuphikiswa kwe-myocardial ku-ischemia-ukuphinda kufakwe kabusha ku-vivo." Am J Physiol Heart Circ Physiol. 2001 Aug; 281 (2): H679-88.
Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. "I-glutathione metabolism nemiphumela yayo empilweni." J Nutriti. 2004 Mar; 134 (3): 489-92.
Ukuziphendulela: Ulwazi oluqukethwe kule sayithi luhloswe ngezinjongo zemfundo kuphela futhi aluthathi iseluleko, ukuxilongwa noma ukwelashwa ngudokotela olayisensi. Akuhloselwe ukumboza zonke izinyathelo zokuqapha, ukusebenzisana kwezidakamizwa, izimo noma imiphumela emibi. Kufanele ufune ukunakekelwa okusheshayo kwezokwelapha kunoma yiziphi izinkinga zezempilo bese uthintana nodokotela wakho ngaphambi kokusebenzisa enye imithi noma wenze ushintsho ohlelweni lwakho.